Roy Nelson challenges Mike Russow to a win or leave (the heavyweight division) bout

In a heavyweight division of the UFC filled with fighters are who built like a Greek god, Roy Nelson and Mike Russow don't exactly fit the mold.? After watching Fabricio Werdum knock out Russow at UFC 147, Nelson was struck with matchmaking inspiration.

"I want Mike Russow and loser goes to 205 or becomes Dana White Rich. Let make it happen @danawhite," Nelson tweeted.

Both men appear to carry more body fat than most of their counterparts and look like they could cut down a weight class. They also both have recent losses to Werdum, as Nelson dropped a decision to him in February.

This isn't the first time Nelson has contemplated a drop down. In March, he said he would try to get to light heavyweight if he added 100,000 Facebook likes. However, he abandoned the plan when he was booked for the all-heavyweight main card at UFC 146.

A drop for Russow, who weighed in at 246 lbs. for UFC 147, may be a bit more difficult than for Nelson. In addition to being a pro fighter, he is a full-time officer in the Chicago Police Department. He doesn't train full-time, like Nelson does.

Of course, the difficulty in dropping down would also give Russow more motivation to win the fight. Do you want to see this fight? Speak your mind in the comments, on Facebook or on Twitter.

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5.7-magnitude earthquake hits SE China

Sunday 24th June, 2012

5.7-magnitude earthquake hits SE China ??

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?????Sunday 24th June, 2012??Source: SINA ??

BEIJING, June 24 (Xinhua) -- A 5.7-magnitude earthquake jolted the border of southwest China's Yunnan and Sichuan provinces at 3:59 p.m. Sunday (Beijing Time), said the China Earthquake Networks Center. The epicenter, with a depth of 11 km, was located at the border area between Ninglang county of Yunnan and Yanyuan county of Sichuan at 27.7 degrees of north latitude and 100.7 degrees east longitude. No information about casualty has been avail... Read the full story at SINA

Breaking News Sunday 24th June, 2012

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Most commonly mutated gene in cancer 'may play role in stroke'

Researchers have found that the gene p53, which is the most commonly mutated gene in cancer, has a novel role in the development of ischemic stroke.

p53 is dubbed the "guardian of the genome" because it blocks cells with damaged DNA from propagating and eventually becoming cancerous.

However, new research led by Ute M. Moll, M.D., Professor of Pathology at Stony Brook University School of Medicine, and colleagues, uncovers a novel role for p53 beyond cancer in the development of ischemic stroke.

The team identified an unexpected critical function of p53 in activating necrosis, an irreversible form of tissue death, triggered during oxidative stress and ischemia.

Ischemia-associated oxidative damage leads to irreversible necrosis which is a major cause of catastrophic tissue loss.

Elucidating its signalling mechanism is of paramount importance. p53 is a central cellular stress sensor that responds to multiple insults including oxidative stress and is known to orchestrate apoptotic and autophagic types of cell death.

However, it was previously unknown whether p53 can also activate oxidative stress-induced necrosis, a regulated form of cell death that depends on the mitochondrial permeability transition pore (PTP) pore.

"We identified an unexpected and critical function of p53 in activating necrosis: In response to oxidative stress in normal healthy cells, p53 accumulates in the mitochondrial matrix and triggers the opening of the PTP pore at the inner mitochondrial membrane, leading to collapse of the electrochemical gradient and cell necrosis," Moll said.

"p53 acts via physical interaction with the critical PTP regulator Cyclophylin D (CypD). This p53 action occurs in cultured cells and in ischemic stroke in mice," Moll said.

They found in their model that when the destructive p53-CypD complex is blocked from forming by using Cyclosporine-A type inhibitors, the brain tissue is strongly protected from necrosis and stroke is prevented.

"The findings fundamentally expand our understanding of p53-mediated cell death networks.

"The data also suggest that acute temporary blockade of the destructive p53-CypD complex with clinically well-tolerated Cyclosporine A-type inhibitors may lead to a therapeutic strategy to limit the extent of an ischemic stroke in patients," Moll said.

Yusuf A. Hannun, M.D., Director of the Stony Brook University Cancer Center, also commented on the role of p53.

"p53 is one of the most important genes in cancer and by far the most studied," Hannun said.

"Therefore, this discovery by Dr. Moll and her colleagues in defining the mechanism of a new p53 function and its importance in necrotic injury and stoke is truly spectacular," he added.

The study has been published online in Cell. (ANI)

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After slow start, Landon Donovan gives Galaxy a spark

One hundred thousand or 200,000 miles seem to be the milestone for the typical car to slow down, after a long life of service to its owner.

What is the parallel in a soccer player's career? Do you judge by years or games played?

Galaxy midfielder Landon Donovan turned 30 in March. During the past decade, he's played in roughly 350 matches that include Major League Soccer and international competitions.

Though Donovan can hardly be considered typical, it was only natural to question how much longer he can be an elite player after a slow start this season for the Galaxy. He scored just two goals in his first 11 games after averaging just a shade under a goal for every two games played during his 12-year MLS career.

Even Donovan hinted at a decreasing passion for the game when talking to reporters at the U.S. national team training camp in May.

"I think all players reach a point in their career where it's natural to lose some of that hunger, that desire, to sort of break out or be a star," he said. "My mind-set now is I want to be successful, and I realize now that as I'm getting older, I'm not going to be the guy who's scoring goals every game or making a great impact all the time."

Donovan has sparked the Galaxy in consecutive wins as the defending MLS champions attempt to crawl back into position to make the playoffs.

With L.A. down, 2-0, Wednesday at Real Salt Lake, the Galaxy fought back to win, 3-2, thanks to Donovan's two goals, and gain a much-needed three points. It was the first time in club history that Real Salt Lake had surrendered a two-goal lead at home.

"I'm doing the same thing," Donovan said after the team's workout Friday. "I'm trying to be a good teammate and a good captain and help this team win.

"I want us to keep playing the way we've been playing. Since the day I've been back, there's been a different mentality and attitude, and we need to continue that. We're still in a big hole, and we've got to make sure we keep winning."

After snapping a seven-match winless streak with consecutive victories and losing various players to rehab, injury, suspension and international duty, the Galaxy might have turned a corner.

Going into Saturday's game against Vancouver, the Galaxy, with a 5-8-2 record, are two points behind Colorado Rapids for the final playoff spot in the Western Conference.

Galaxy Coach Bruce Arena said his squad is playing more like the team they were expected to be entering the season, and that much of that is due to Donovan's leadership.

"He's certainly shown since he returned that he wants to lead this team and be successful," Arena said, adding that there's "no question" he has played more inspired in recent weeks.

Only time will tell how many miles Donovan has left in the tank, but if the past couple of weeks are any indication, he still has quite a few rides left in him.

andrew.owens@latimes.com

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Giving to religious institutions drops for second year in a row. Why?

Giving to religious groups has slipped by a cumulative 3.7 percent since 2010. Still, religion remains America?s favorite charitable cause, with $95.88 billion in donations.

By G. Jeffrey MacDonald,?Correspondent / June 22, 2012

In this April photo, a man removes a section of stained glass from its frame during restoration at First United Methodist Church in Frankfort, Ky.

Hannah Reel/The State Journal/AP

Enlarge

Church congregations may need to pass the offering plate again because giving to religious institutions has dropped for the second year in a row.

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Charitable giving to the religious sector fell by 1.7 percent last year, according to the Giving USA 2012 report released this week. Since the start of 2010, giving to religious groups has slipped by a cumulative 3.7 percent (not adjusted for inflation).

This shows religion to be lagging in the evermore intense competition for donor dollars, even as other nonprofit sectors gain. Total charitable giving rose by 4 percent in 2011 to $298.4 billion. Of the eight sectors tracked by Giving USA, seven saw donations rise in both 2010 and 2011. Only religion lost ground.

Why is religion having a hard time?

?Declining attendance at religious services is part and parcel to the issue? of struggling to maintain or increase giving levels, says Robert Evans, a Philadelphia fundraising consultant for nonprofits and an author of the Giving USA 2012 report. ?If you have fewer people coming through the front door, then how do you do it??

But despite cutbacks in giving, religion remains America?s favorite charitable cause. With $95.88 billion in donations, faith-based organizations still collect far more than any other nonprofit segment. A distant second is education with $38.9 billion, followed by human services at $35.4 billion.

Yet religious institutions could be witnessing the start of a long-term slide, observers say. Precipitating factors, such as a weak economic recovery, portend more financial stress and hard choices about where institutions should cut in years ahead, according to David Roozen, director of the Hartford Institute for Religion Research at Hartford Seminary in Connecticut.

?The recession exacerbated downward pressure on church finances,? Mr. Roozen says. ?You?ll likely see a continuation of this? as unemployment and wage stagnation limit how much churchgoers can give.

Large congregations have fared best in the recession?s aftermath, Roozen says, as they consume a larger share of a shrinking pie. Slumping donations have translated into painful staff cuts for small congregations and denominational offices. In one telling sign, the United Methodist Church this year did away with its longstanding policy of guaranteeing appointments for clergy as churches come to rely on fewer pastors and part-timers for ministry.

Shrinking attendance isn?t all that?s hampered the faithful?s fundraising efforts, according to Mr. Evans. Religious institutions have largely failed to keep pace with other types of organizations, such as colleges and hospitals, in deploying professional development teams. Synagogues that employ professional fundraisers have found the investment pays off, Evans says, but most congregations have no one trained in the art of asking for money.

?There?s no donor fatigue,? says Evans, who is managing director of EHL Consulting Group. ?But houses of worship ... need to fine-tune their message more strongly for the people who want to make this a better country.?

What?s more, religious institutions are exempt from financial disclosure requirements that bind other nonprofits. As donors become more discreet and sophisticated, Evans says, they?ve come to expect more transparency than religious bodies are used to supplying. Donors who value transparency might therefore respond more favorably to nonreligious appeals.

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Google stock split wins approval; CEO loses voice

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